Protein Details: Aquaporin-1

Protein ID

ICDB_Pro_0744

Protein Name

Aquaporin-1

Gene Name

Aqp1

Organism

Mus musculus (Mouse)

Length

269 amino acids

AlphaFoldDB

AF-Q02013-F1-model_v4.pdb

Function

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water;thereby permitting water to move in the direction of an osmotic gradient . Component of the ankyrin-1 complex;a multiprotein complex involved in the stability and shape of the erythrocyte membrane (By similarity).

Sequence

MASEIKKKLFWRAVVAEFLAMTLFVFISIGSALGFNYPLERNQTLVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISILRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGRNDLAHGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDFTDRMKVWTSGQVEEYDLDADDINSRVEMKPK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 56: "Substrate discrimination"; SITE 180: "Substrate discrimination"; SITE 189: "Hg(2+)-sensitive residue"; SITE 195: "Substrate discrimination";

Disease

Endotoxemia; Acute kidney injury; Bronchitis; infantile gastroenteritis; cardiac hypertrophy

Location

Detected in erythrocytes (at protein level) (PubMed:12133842). In the kidney;expressed on luminal and basal borders of proximal tubules and in the thin limb of Henles loop (at protein level) (PubMed:31605441).

DOI ID

10.1128/mcb.12.9.3919-3929.1992; 10.1126/science.1112014; 10.1101/gr.2596504; 10.1016/s0896-6273(00)81174-5; 10.1074/jbc.m206948200; 10.1073/pnas.0609836104; 10.1016/j.cell.2010.12.001; 10.1111/febs.15088

RefSeq

NP_031498.1